Medical Devices

How to choose the right coronary stent?

How to choose the right coronary stent?

We all are aware of Angioplasty and how it can save lives and reduce heart muscle damage by restoring constant blood flow to the heart. In recent years, Angioplasty and Stenting have shown life-enhancing and sometimes life-saving option for a lot of people suffering from blocked arteries. It has been really effective in treating heart attacks and strokes while improving the quality of life. And, if the success rate and worldwide acceptance of the surgery has already convinced you to opt for Angioplasty then it is also important to know and choose the right kind of coronary stents that adheres to ultimate efficacy and safety.

Though the modern era offers multiple designs, shapes and sizes, we've got a few tips for you that can help you in selecting an optimal stent for a particular patient. 

  1. Evaluate efficacy

Initially, key opinion leaders (KOLs), specifically, from the West were “obsessed” with some angiographic performance parameters associated with DES such as restenosis, late lumen loss, and potency of anti-proliferative drugs present in DES in neo-intimal hyperplasia reduction within stented segments. Back then, efficacy was “of paramount importance” to interventional cardiologists, and several evidence comparing different DES was based primarily on their efficacy versus “more clinically relevant and vital events like repeat revascularization.” Current experts are lucky to have numerous DES choices, fine-tuned with a majority of them demonstrating similar effectiveness. As a result, the decision to prefer one stent over another might not be as well-versed by comparative differences in efficacy as in the past. “With current DES, the 1-year rate of repeat revascularization is less than 5%—almost free of the stent’s type or the type of anti-proliferative drug. It is a vivid difference as compared to the initial scenario.” Now, the more likely relevant challenge lies in recognizing the minute differences in outcomes among modern DES.

  1. Considering safety

While removing the overall occurrence of blood clotting within the stent, remains an objective, modern DES designs have reduced the event rate to such an extent, that clinicians are more confident in using DES to treat patients previously considered at higher risk. Relative evidence now challenges the role of bare metal stents (BMS), and this doubt is reflected across the global clinical practice. .

  1. Thoughtful deliverability

Cardiologists opine that stent deliverability and performance are as important as safety and effectiveness when considering multiple options. While deliverability is relevant, it is more vital to consider that though a procedure may be more convenient with a particular device compared with another. It is not really in perspective with the following 15 years or more for the life of the patient. So if a stent is simple to implant and works best for the patient, it is awesome. But if the patient would gain more from a device that is a little riskier to the implant, sharpen your skill, and face the challenge. Attention to the method will be ever more vital with approaching acceptance of bioresorbable scaffolds in clinical practice.

Bioresorbable Scaffolds

  1. Examine DAPT adherence

The debate of BMS versus DES is not as intense as it once was, but bearing in mind the adherence factor of blood thinner therapy after stent implantation to prevent clots and its duration might influence your decision in a particular direction. That said, recently revised guidelines now endorse blood thinner therapy of less than 1 year in selected patients treated with contemporary generation DES. Still, if “patients possess a high risk of bleeding or their compliance is challenged with long-term blood thinner therapy,” BMS has traditionally been considered the better option. However, recent evidence has challenged this belief, proposing that even with shortened DAPT durations, modern DES have similar rates of blood clotting within the stent and superior rates of decreasing restenosis versus BMS. “Overall, the use of BMS in clinical practice is getting reduced day by day”. Also, observational reports indicate a lower risk of adverse events after non-cardiac surgery in patients treated with DES versus BMS. Until more conclusive evidence can give more clear-cut answers on this issue, BMS may hold some market share, however, their scope of use “is increasingly getting narrowed.”

  1. Geometry matters

Geometry is the main differentiating factor among the newest-generation DES choices in terms of performance. Their capacity for expansion? Their strut cell design? Their radial strength and scaffolding properties? If the stent struts are thin or ultrathin, what are the chances of stent distortion? As a lot of comparative research has been performed on stents, learning up, inside and out, on experience and knowing the geometrical structures of the devices you use, is recommended. Thinking about stent geometry for visibility is also recommended. The thinner the struts, the harder it is to visualize the stent”. Also, manufacturers are now ingeniously implanting metals like iridium, molybdenum, or platinum within the devices to raise their radio-opacity.

  1. Size appropriately

Many of the early imaging studies emphasized that, despite the angiographic look of the vessel, interventional cardiologists frequently practice a model of geographic miss. “Here, they stent the vessel, but leave residual disease in many segments not sufficiently covered by the stent”. So while considering stent selection, it is vital to ascertain which device will be suitable to cover the entire diseased segment of the vessel, if possible. Allowing for the diameter of the vessel is essential as well as the ultimate predictor of recurrent vessel narrowing with current-generation DES is using less than the normal size (undersized) of the stent in the vessel itself. Fitting expansion of the stent and sizing of the stent and attaining the largest permissible minimal luminal area of the stent are vital features in reaching the best outcomes for the patient.”

  1. Know your polymers

DES release drugs and hence, you should be aware of each of their features and also the polymers eluting them. Precisely knowing drug release rates, safety and efficacy profiles, and their influence on clinical outcomes are recommended. Most current DES designs also include robust polymers that permanently stay with the stent itself. Although new bioresorbable-polymer stents are approved for use, and other designs are in ongoing studies, whether they will “confer an added safety or biocompatibility advantage or not, remains under study.” 

  1. Adapt for specific lesion subsets

While treating complex lesions, being aware of which stent is best for specific lesion types is recommended. “As the playing field is currently leveled with the availability of multiple DES, it is tough to recommend a particular stent brand for a particular lesion subset. “On the contrary, it also does not mean we should assume a generalized approach for all DES. There are certain settings in which specific stent types have been more extensively studied and therefore may be preferred.” So while we may not have a definitive answer on which stent to use for each situation, attention must be paid to the full amount of data.

  1. Develop cost sensitivity

The fact that different DES brands are now more similar than before in terms of safety and efficacy “has motivated many different hospital programs to largely determine their inventory of stents based entirely on cost. Although there are varied other reasons for an interventional cardiologist’s selection of one stent over another, they need to “develop a sensitivity for costs related to the DES.” Cost depends on a hospital’s purchasing volume and also the cost per stent. “Even with a difference of 100 per stent between two stent brands, if you are doing several thousand procedures a year, it translates into several hundred thousand.”

  1. Always be ready to explain your choice

It is observed that because of the design of the training programs, practitioners often learn to imitate the choices of their teachers, especially in terms of stent selection. The presence of manufacturers’ representatives in the catheter lab can also add confusion. But irrespective of the eventual reason for the practitioner’s choice, they must accept the changing aspects influencing stent selection and question themselves with every case they perform. Challenging themselves and encouraging mutual discussions as operators and colleagues “is a positive experience that keeps them grounded in the need for science, and why they practice the way they do.” It is also important for each interventionalist to constructively question their coworkers, even if they are more senior than them so that everyone holds each other accountable.

It is given that as we age, the evolution in technology and science will continue to bring in more and more effective stent choices that will have a better impact on the lives of the patients. Hence, Meril is committed to lead innovation by developing a strong pipeline, patient centric innovative products to offer in future thus adding more to life globally. In the end, it will be a call that will depend on a detailed study, efficacy, and safety.